The effect of meal composition on postprandial glucagon-like peptide-1 response in overweight/obese participants
نویسندگان
چکیده
Background Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted in the intestine in response to food intake. GLP-1 may be responsible for nearly 50% of insulin secretion. Postprandial GLP-1 secretion may be impaired in overweight/obese (OW/O) individuals and in patients with type-2 diabetes (T2D). Meals high in protein (HP) or high in monounsaturated fat (HMF) may increase GLP-1 response. However, there are no studies directly comparing HP with HMF meals on postprandial GLP-1 response.
منابع مشابه
A walnut-containing meal had similar effects on early satiety, CCK, and PYY, but attenuated the postprandial GLP-1 and insulin response compared to a nut-free control meal
Regular nut consumption is associated with lower adiposity and reduced weight gain in adulthood. Walnut feeding studies have observed minimal effect on body weight despite potential additional energy intake. Several mechanisms may explain why consuming nuts promotes weight control, including increased early phase satiety, possibly reflected in postprandial response of gastrointestinal and pancr...
متن کاملDifferential effects of proteins and carbohydrates on postprandial blood pressure-related responses.
Diet composition may affect blood pressure (BP), but the mechanisms are unclear. The aim of the present study was to compare postprandial BP-related responses to the ingestion of pea protein, milk protein and egg-white protein. In addition, postprandial BP-related responses to the ingestion of maltodextrin were compared with those to the ingestion of sucrose and a protein mix. We hypothesised t...
متن کاملA high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men
It is known that the macronutrient content of a meal has different impacts on the postprandial satiety and appetite hormonal responses. Whether obesity interacts with such nutrient-dependent responses is not well characterized. We examined the postprandial appetite and satiety hormonal responses after a high-protein (HP), high-carbohydrate (HC), or high-fat (HF) mixed meal. This was a randomize...
متن کاملThe effect of slow spaced eating on hunger and satiety in overweight and obese patients with type 2 diabetes mellitus
BACKGROUND Slow spaced eating is associated with improved satiety and gut hormone responses in normal-weight participants. This crossover study compared the effect of slow and rapid eating patterns on hunger, fullness, glucose, insulin, and the appetite-related gut hormones peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and ghrelin in overweight and obese participants with type 2 diabetes m...
متن کاملGlucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men.
The gut peptide glucagon-like peptide 1(7-36) amide (GLP-1) is released into the circulation after food intake. GLP-1 has been shown to have an incretin effect and inhibits gastrointestinal motility in humans. In rats, intracerebral administration of GLP-1 results in reduced food intake. Obese humans have been found to have an attenuated plasma GLP-1 response to a mixed meal. To approximate the...
متن کامل